What Does CBG Do?

CBG stimulates appetite and may be useful for people suffering from eating disorders. It can also reduce glaucoma by lowering eye pressure. It has been shown to suppress the growth of cancer cells and inhibits bacterial biofilm formation.

Pre-clinical studies show that CBG can protect the nervous system from damage caused by physical trauma. It also soothes pain and counteracts inflammation and oxidative stress.

Anti-inflammatory

CBG is one of the primary cannabinoids responsible for the anti-inflammatory effects of marijuana. It interacts with receptors in your body that control inflammation, and it can reduce the synthesis of inflammatory messengers like TNF-alpha. This can help manage pain and other symptoms that are associated with chronic diseases.

It also has analgesic properties, meaning that it can reduce pain signals that are sent to your brain. This is because it inhibits the activity of certain cells that amplify pain signals in your brain, much like a volume knob on a stereo. The ability of CBG to reduce pain signaling may provide relief for people suffering from neuropathic pain, which is caused by damage to the nerves themselves.

Unlike THC and CBD, CBG does not produce a high, so it is an excellent option for people who want to avoid psychoactive cannabis products. It can be found in a wide variety of products, including gummies and tinctures. These products can be used to relieve a wide range of conditions, from anxiety and depression to PTSD and ADHD.

CBG is also an excellent choice for reducing GI issues, including Irritable Bowel Syndrome (IBS) and Crohn’s disease. Studies have shown that it can help reduce the production of nitric oxide and reactive oxygen species, which are responsible for inflammation in the digestive tract. CBG is also believed to promote healthy digestion by stimulating appetite.

Pain-relieving

CBG is a powerful pain-relieving treatment because it interacts with the endocannabinoid system. This system is responsible for balancing your body’s internal processes, including controlling the perception of pain and reducing inflammation. CBG binds to the CB1 and CB2 receptors, which are found throughout the nervous system and body. It also inhibits GABA reuptake, which helps reduce the perception of pain. In addition, CBG acts as a natural antidepressant and may improve mood.

In preclinical studies, CBG has been shown to reduce nociception and mechanical hypersensitivity induced by phenyl benzoquinone and cisplatin in mice. It can also mitigate chronic inflammation, which is a common cause of neuropathic pain. CBG is unique in that it can address both symptom and root cause of nerve-related pain, making it a promising candidate for treating conditions like fibromyalgia and multiple sclerosis.

In addition to its pain-relieving effects, CBG can help with gastrointestinal issues like Irritable Bowel Syndrome (IBS) and Crohn’s disease. A study published in 2019 found that IBS and Crohn’s are caused by clinical endocannabinoid deficiency, and that CBG can stimulate gut motility and relieve symptoms. It can also be helpful in managing stress-related digestive problems. This is because of its ability to regulate the release of serotonin in your gut.

Anticancer

CBG has anticancer properties and may be an effective alternative to conventional chemotherapy. Studies show that it inhibits tumor growth and suppresses cellular migration and invasion. It also blocks ERK and mTOR protein activation, which are involved in cancer progression. Moreover, it is known to activate PPARg and SOD-1, two antioxidant enzymes that help control oxidative stress. In addition, it can help to reduce cholesterol levels and protect the nervous system.

Recent research suggests that CBG can alleviate gastrointestinal discomfort and reduce symptoms of Irritable Bowel Syndrome (IBS). It can improve gut motility, reduce inflammation and increase GABA levels in the brain. This can help to relax muscles and other structural substances, which in turn can improve cognitive function. CBG may also be beneficial for those with metabolic syndrome, a condition characterized by abdominal obesity, hypertension, high triglyceride and low high-density lipoprotein (HDL) cholesterol levels.

In a study, Aljobaily and coworkers found that CBG reduced hepatic inflammation and fibrosis in mice with non-alcoholic steatohepatitis (NASH). The compound also enhanced recruitment of quiescent mesenchymal stem cells into bone marrow. However, further studies are needed to examine the effects of CBG on hepatic inflammation in human patients with NASH.

Antibacterial

CBG has been shown to have antibacterial properties, especially against Gram-positive bacteria like Staphylococcus aureus (including the methicillin-resistant strain known as MRSA). It is also effective against some Gram-negative bacteria such as Vibrio harveyi, which causes many hospital-acquired infections. In one study, CBG was more effective than erythromycin and tetracycline in inhibiting the growth of MRSA cells.

Moreover, this terpene shows great promise in treating inflammatory skin conditions. In fact, a clinical trial using 0.1% CBG in human serum significantly reduced transepidermal water loss and the appearance of redness following sodium lauryl sulfate treatment. CBG was also found to significantly reduce the activity of pro-inflammatory proteins in human keratinocytes.

Chronic inflammation is a contributing factor to a wide variety of health conditions, including rheumatoid arthritis, diabetes, inflammatory bowel disease, and asthma. Research suggests that CBG and its metabolites may be effective in reducing the symptoms of these diseases by controlling neuroinflammation and oxidative stress.

Another benefit of CBG is its ability to stimulate the appetite. In a laboratory study, it was found to be an effective appetite stimulant without producing any psychoactive effects. This makes it an excellent choice for people suffering from loss of appetite due to cancer or other health conditions. It is also helpful in treating gastrointestinal disorders such as IBS and Crohn’s disease.

Antipsychotic

CBG is a potential antipsychotic treatment, as it blocks receptors in the brain that produce psychoactive effects. It also reduces anxiety and stress, and helps regulate mood. One study found that CBG reduced state anxiety ratings in participants on a 10-point scale. However, this finding was limited by the retrospective self-report nature of the study and the use of a preparation with varying levels of CBG concentrations. Another study found that CBG improved verbal memory compared to placebo without any evidence of intoxication or impairment.

Another study showed that CBG had antinociceptive effects in two pain models, including carrageenan-induced inflammatory pain and neuropathic pain in CIA mice. It acted by activating TRPV1 and blocking the transmission of pain signals to HaCaT cells. It also stimulated the release of b-endorphin, a naturally occurring opioid that reduces pain and inflammation in the body.

The endocannabinoid system (ECS) is responsible for regulating homeostasis in the body, and CBG interacts with both CB1 and CB2 receptors to promote and inhibit certain reactions. Unlike THC, CBG does not produce a high and has a low abuse potential, so it is a safe option for patients with psychiatric conditions. However, it is important to note that patients should talk with their physicians before trying any new supplement or medicine.

Antioxidant

CBG acts as a powerful antioxidant that protects the body against inflammation and oxidative stress. It has been shown to promote the pro-survival of neural progenitor cells and reduce cellular toxicity caused by quinolinic acid (QA) and accumulated mutant huntingtin aggregates in Huntington’s disease patients. It has also been shown to protect against the neurotoxicity induced by LPS in NSC-34 neurons and decrease inflammatory markers including IL-1, IL-6, and lactate dehydrogenase. It has also been shown to inhibit COX enzymes and block the voltage-gated sodium channels Nav 1.1, 1.2, and 1.5.

In addition, CBG has been shown to increase the concentration of endocannabinoids like anandamide (AEA), which is known as the bliss molecule for its ability to induce feelings of happiness. It also appears to inhibit the CYP2J2-dependent metabolism of AEA by more than 30%.

While research is ongoing, CBG has the potential to be an effective treatment for conditions such as irritable bowel syndrome, chronic pain, and anxiety. It may also be useful for treating autoimmune disorders, arthritis, and other inflammatory conditions. Because it interacts with the endocannabinoid system, it is important to look for products that have been third-party laboratory tested. This ensures quality and consumer safety. It is also recommended to speak with a physician before taking any new supplements.

Blood pressure-regulating

CBG is a powerful anti-inflammatory that can help people with high blood pressure and other cardiovascular conditions. It works by interacting with the alpha-2 adrenergic receptors and inhibiting glutamate. It also promotes serotonin durations and reduces the stress response.

It can also improve your digestive health. It stimulates the production of nitric oxide and reduces the amount of reactive oxygen species in your gut. These effects are especially important for people with Irritable Bowel Syndrome (IBS).

Research has shown that CBG may decrease inflammation in the brain by activating the PPAR receptors. PPAR receptors are part of the nuclear genome and control how your genes are expressed. They are also involved in the formation of neurons in the hippocampus, which helps us remember and learn things.

In a study conducted on mice, acute CBG administration significantly lowered blood pressure. The doses used in the study were not clinically relevant for human patients, but higher doses have been reported to be effective in rodents models of neurodegenerative diseases and inflammatory bowel disease. A similar result was seen in a recent human trial, where CBG was found to be effective at lowering blood pressure. However, the results of these trials need to be corroborated through double-blind, placebo-controlled studies.