CBG Benefits

CBG is the precursor for many other phytocannabinoids, such as THC and CBD. Though it received less attention early on due to THC and CBD's popularity, preclinical research shows CBG has a broad spectrum of therapeutic effects.

These include stimulating appetite, lowering intraocular pressure in glaucoma, protecting nerve cells in Huntington's disease, and more. It also inhibits cancer growth and decreases tumor cell migration in animal models of colorectal cancer.

Anti-Inflammatory

CBG is an effective anti-inflammatory and can help to alleviate pain. It does this by interfering with a system in your body that regulates the way that pain signals are transmitted to your brain. This makes it a great option for reducing conditions like chronic pain or neuropathic pain caused by nerve damage. It also interacts with the receptors in your endocannabinoid system to reduce the activation of certain pathways that cause pain signals to be transmitted to your brain.

Studies on cellular level have demonstrated that CBG has anti-tumorigenic properties and impedes tumor growth by preventing cell proliferation, inhibiting cell migration, and causing cell death. It has shown anti-tumor effects in human prostate cancer and glioblastoma cells, as well as slowed growth of colon tumors in an experimental model. In addition, it has been found that CBG blocks mTOR and EGFR in pancreatic adenocarcinoma cells, and reduces downstream RAS signaling.

Additionally, CBG has been found to promote apoptosis in hepatocellular carcinoma cells and decrease the expression of CHOP (transcription factor that controls cell cycle progression). It also possesses antibacterial properties and can kill bacteria strains like Staphylococcus aureus and methicillin-resistant Staphylococcus aureus.

Another study found that CBG was able to prevent metabolic syndrome in mice by reducing insulin resistance, blood glucose, triglycerides, and cholesterol levels. It achieves these effects by promoting lipid metabolism and inhibiting AMPK-/mTOR pathway activation.

In the same study, it was found that CBG reduced inflammation by interacting with the cannabinoid receptor CB2R and reducing iNOS protein levels in LPS-stimulated macrophages. It was also found to significantly reduce oxidative stress in these cells.

CBG has also been found to protect the brain by reducing the toxicity of oxidative stress and protecting against neuroinflammation. It has been shown to protect against ischemic injury by reducing TNF- and lactate dehydrogenase in astrocytes and pericytes of the blood-brain barrier.

Additionally, CBG has been found to increase the concentrations of GABA in your brain, which increases mood and promotes a state of calmness. As such, it is a natural antidepressant that may offer relief from anxiety and depression.

Pain Reliever

CBG’s interaction with pain receptors makes it a powerful analgesic. It also works to calm the nervous system, providing a sedating effect that may help alleviate stress and anxiety. It’s a natural antidepressant, with the ability to stimulate serotonin production in the brain, helping regulate mood and reduce symptoms of depression and anxiety.

CBg is effective at reducing inflammation and nerve damage, making it a potential treatment for inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis. CBG has been shown to reduce nitric oxide in cells, which may help alleviate inflammation and symptoms associated with these conditions. It’s also been used to treat glaucoma, by lowering blood pressure in the eye and brain.

Studies have shown that CBG can reduce oxidative stress and the resulting neuroinflammation in the brain, providing protection for neurons. It is one of the cannabinoids being investigated for its potential neuroprotective effects in Huntington’s disease and Parkinson’s disease.

Research has found that CBG can stimulate the growth of new neurons in the hippocampus, a region of the brain responsible for memory and learning. It can also improve the function of existing neurons, potentially speeding up memory and learning processes. It’s been found to increase levels of BDNF, a protein that helps protect and repair damaged neurons.

It is possible that CBG can help ease chronic pain by interacting with the body’s GABA receptors. This can soften muscle and other structural materials, as well as boosting the endocannabinoid system to alleviate tension and mood.

Although it is rare to find a cannabis product that contains only CBG, it is possible to experience its benefits when it is combined with other cannabinoids such as THC or CBD. This can impact the strength of the results, and also how quickly you feel them. If you’re considering trying a CBG-only product, be sure to speak with a physician before beginning use. They can help ensure that this is the right medicine for you and determine an appropriate dosage. The best way to receive the most benefit from a CBG-only product is to consume it orally via a tincture, sublingually (under the tongue), or vaped in oil form.

Sleep Aid

CBG has sleep-enhancing properties that may help you get a better night’s rest. Its calming effects can quiet racing thoughts and relieve tension in the body, which can make it easier to fall asleep and stay asleep. It also shows promise in regulating circadian rhythms, which can promote more restful sleep by balancing the sleep-wake cycle. A 2023 study even found that CBG has antibacterial properties, which could make it helpful in fighting the bacteria that can cause infections and other symptoms that disrupt sleep.

While more research is needed, many people report that CBG can help them to fall asleep and stay asleep. Some report that it promotes deep sleep throughout the night, and others say it helps them to wake up feeling rested in the morning. Its unique interaction with different receptors and neurotransmitters may be the key to its effectiveness in enhancing sleep quality.

If you have trouble sleeping, try using a tincture made with CBG. It can be taken sublingually for rapid absorption, and it’s easy to adjust the amount you take based on your needs. Tinctures are available in a wide range of formats, from simple dropper bottles to convenient gummies and other portable products. You can find a full selection of premium CBG tinctures and other sleep-enhancing hemp products at Mellow Fellow, where you can choose from a variety of delivery methods to suit your preferences.

The sedative effects of CBG are similar to those of CBD, although it is less likely to induce drowsiness than THC. Both cannabinoids are effective for promoting sleep, but it’s important to consider your specific physiology and sleep issues before choosing one over the other.

If you’re combining CBD and CBG for sleep, you’ll want to ensure you’re taking them at the right times to maximize your sleep benefits. CBG’s sedative effects are most beneficial when it’s taken at night, while CBD’s anti-anxiety properties are more suited for use during the day. You can further increase the effectiveness of your regimen by incorporating other natural sleep aids like melatonin, ginger, lemon balm, ginseng, or ingredients that provide energizing effects.

Weight Loss

CBG has been known to stimulate appetite and may be a useful treatment for conditions that involve malnutrition. It has been shown to increase the expression of PPARa and PPARg receptors, which may lead to greater metabolism and calorie burning, thus aiding in weight loss.

Cbg benefits include its ability to prevent high-fat diet-induced weight gain, and it also improves insulin sensitivity. This makes CBG a potential treatment for metabolic syndrome, which can be associated with heart disease and type 2 diabetes.

Another cbg benefit is its anti-inflammatory properties, which may help ease the symptoms of digestive conditions like Crohn’s and ulcerative colitis. It can do this by inhibiting the production of inflammatory enzymes, such as inducible nitric oxide synthase (iNOS) and diacylglycerol lipase (DAGL).

In a study, cbg was found to be effective at treating mice with inflammation. It worked by preventing the accumulation of fat in the liver, decreasing levels of ALT and AST in blood, and increasing the synthesis of glucose.

The research also pointed out that cbg has potent neuroprotective capabilities. This can be useful in the treatment of neurological disorders, such as Huntington’s disease, as it reduces damage to nerve cells. It can do this by enhancing the effects of THC and CBD on neurons.

Lastly, cbg has anti-emetic (anti-nausea) properties. This is especially important for people with nausea related to chemotherapy and other medical treatments. It can do this by blocking the CB1R receptors and by reducing the activity of inducible nitric oxide synthase and iNOS in macrophages.

To get the most out of cbg, look for products with a 1:1 ratio of cbg to CBD. This will provide the best combination of anxiety relief, pain relief, and appetite stimulation. You can find these products by searching online or asking your local dispensary for recommendations. However, you should always talk to your doctor before trying any cannabis product. They can ensure that it’s safe for you and will not interfere with any prescription medications you are taking. They can also help you determine the right dosage.